Complete Genomics’ novel sequencing technology combined with its unique business model is enabling human genome sequencing to be conducted at an affordable price and unprecedented scale.

Complete Genomics’ sequencing system was created around four core considerations:

Scale

Uses massively parallel biochemistry and computing, which means that by 2010 it will be able to sequence thousands of genomes as part of a drug or disease study.

Quality

Delivers clinical quality data by combining high-coverage shotgun sequencing technology with specialized biochemical and computational technologies designed to address the unique characteristics of human genomes.

Price

Sequences complete human genomes for a small fraction of the cost of current second-generation sequencing technologies.

Focus

Complete Genomics’ technology is developed specifically for sequencing and interpreting data from large numbers of human genomes. Complete Genomics’ sample preparation processes are designed especially for the human genome, and its software is optimized for assembling and analyzing human DNA. Furthermore, Complete Genomics’ technologists are highly specialized experts in the field of human DNA sequencing.

Key Technology Benefits

• Much lower cost than alternative approaches due to low reagent usage and high imaging efficiency
• Robust, proprietary biochemistry approach and powerful library structures provide the high level of accuracy required to resolve complexities of the human genome
• Highest throughput available: Currently at 6Gbp (Billion Base Pairs) per instrument per day
• Multiple paired end libraries, which resolve the most common repeat structures in the human genome
• Long fragment reads (virtual 100kb read length) that enable independent sequencing of the two sets of parental chromosomes in a diploid genome